Django REST Framework (DRF) simplifies building powerful REST APIs. Start by creating a Django project and djangorestframework. Define models for your data structure using Django ORM. Create serializers to convert complex data types to JSON. Serializers validate input data and handle deserialization. ViewSets group related views for a model, reducing code duplication. Routers automatically generate URL patterns from ViewSets. Authentication options include Session, Token, and JWT authentication. Permissions control access at view or object level. Throttling prevents API abuse with rate limiting. Filtering, searching, and ordering are built-in features. Pagination handles large result sets efficiently. Relationships are handled through nested serializers and hyperlinks. Version your API using URL namespaces or accept headers. Write tests for your API endpoints using DRF's test utilities. Documentation can be auto-generated with drf-spectacular or Swagger. Custom actions beyond CRUD use @action decorator. DRF's browsable API is excellent for development and debugging. Django REST Framework is production-proven for building maintainable APIs.